Protein Details: Potassium channel subfamily K member 5

Protein ID

ICDB_Pro_0295

Protein Name

Potassium channel subfamily K member 5

Gene Name

KCNK5; TASK2

Organism

Homo sapiens (Human)

Length

499 amino acids

AlphaFoldDB

AF-O95279-F1-model_v4.pdb

Function

pH-dependent;outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.

Sequence

MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFVFMVTEGWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKNRVPTLEEVSQTLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDASITFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAKAPLNMGEFPSSSESTFTSTESELSVPYEQLMNEYNKANSPKGT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Torsion Dystonia 1 and Birk-Barel Syndrome

Location

Abundant expression in kidney;also detected in liver;placenta and small intestine. In the kidney;expression is restricted to the distal tubules and collecting ducts (PubMed:9812978). Not expressed in proximal tubules or glomeruli (PubMed:9812978). Not expressed in proximal tubules or glomeruli (PubMed:9812978). Not expressed in proximal tubules or glomeruli (PubMed:9812978).

DOI ID

10.1074/jbc.273.47.30863; 10.1038/bjp.2008.213; 10.1038/ng1285; 10.1038/nature02055; 10.1101/gr.2596504; 10.1080/0968768031000084181; 10.1016/j.molcel.2008.07.007

RefSeq

NP_003731.1;